What condition might result from a severe deficiency in blood coagulation factors?

A severe deficiency in blood coagulation factors leads to hemophilia, a genetic disorder characterized by the inability of blood to clot properly. This occurs because the body lacks sufficient amounts of specific coagulation proteins that are essential for the clotting cascade, primarily factor VIII in hemophilia A and factor IX in hemophilia B. As a result, individuals with hemophilia experience prolonged bleeding episodes, easy bruising, and increased risk of bleeding from minor injuries, which can lead to serious health complications.

In contrast to hemophilia, leukemia is a type of cancer that affects blood cells and bone marrow, while thrombosis involves the formation of a blood clot within a blood vessel, which is typically not indicative of a deficiency in coagulation factors. Anemia refers to a deficiency in red blood cells or hemoglobin, affecting oxygen transport in the body rather than clotting.